Magwene Lab |

Members

Paul Magwene, Principal Investigator

Paul Magwene

My research is aimed at understanding how genetic networks work and how they have evolved. More specifically, my lab combines wet lab experimental techniques and the development of computational and statistical methods in order to characterize the properties of gene regulatory networks. A primary goal is to identify how genetic and environmental variation affects the functioning of signaling and regulatory networks, and how in turn this variation relates to relates to intra- and interspecific patterns of phenotypic variation.

Email: paul.magwene@duke.edu


Graduate Students

Cullen Roth

Cullen Roth

Cryptococcal disease is estimated to affect a quarter of million people and cause approximately 180,000 deaths annually. Environmental isolates of Cryptococcus neoformans, and its relative Cryptococcus deneoformans, vary in their pathogenicity, ranging from benign to hyper-virulent. Traits associated with virulence such as the ability to grow at human body temperature (37°C), have been identified. However, little is known about the genetic basis of this phenotypic variation. In the Magwene lab, my work centers around developing Cryptococcus into a model organism for studying quantitative traits. Specifically traits associated with virulence.

Email: cullen.roth@duke.edu

Thomas Sauters

Thomas Sauters

Email: thomas.sauters@duke.edu


Research Personnel

Debra Murray (Lab manager / Research scientist)

Debra Murray

Debra got her PhD in entomology, study the systematics of neotropical butterflies. Debra is involved in myriad projects in the Magwene lab, most prominently our ongoing QTL mapping and experimental evolution projects. In addition to her research, Debra is in charge of ordering, lab safety, and generally helping to keep the trains running on time!

Email: dm125@duke.edu


Undergraduate Students

Are you a Duke undergrad interested in research? Contact us!


Previous Members of the Lab